Zebularine is a DNA methylation inhibitor which acts by forming a covalent complex with DNMT. It displays antiangiogenic activity and markedly inhibits vessel formation in different tumor models. It reactivates silenced E-cadherin and potentiates the effects of other epigenetic therapeutics such as vorinistat. Induces differentiation of mesenchymal cells into cardiomyocytes. Inhibits cytidine deaminase.
Product Details
| Alternative Name: | 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside |
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| Formula: | C9H12N2O5 |
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| MW: | 228.2 |
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| CAS: | 3690-10-6 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in water (>25 mg/ml) or DMSO (>25 mg/ml). |
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| Application Notes: | Can be used for in vitro or cell based studies. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli: D.C. Marciano, et al.; Nat. Commun.
13, 3189 (2022),
Abstract;
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells: M. Billam, et al.; Breast Cancer Res. Treat. Inst.
120, 581 (2010),
Abstract;
Zebularine reactivates silenced E-cadherin but unlike 5-Azacytidine does not induce switching from latent to lytic Epstein-Barr virus infection in Burkitt's lymphoma Akata cells: S.P. Rao, et al.; Mol. Cancer
6, 3 (2007),
Abstract;
Angiostatic activity of DNA methyltransferase inhibitors: D.M.E.I. Hellebrekers, et al.; Mol. Cancer Ther.
5, 467 (2006),
Abstract;
Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases: L. Zhou, et al.; J. Mol. Biol.
321, 591 (2002),
Abstract;
