Tanshinone IIA is a diterpenoid naphthoquinone found in the traditional Chinese medicine Tanshen (Salvia sp). It inhibits AP-1 activity by suppressing jun-fos-DNA complex formation (IC50=0.22 µM) and induces apoptosis in a variety of cell lines
Product Details
| Formula: | C19H18O3 |
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| MW: | 294.3 |
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| CAS: | 568-72-9 |
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| Purity: | ≥93% (HPLC) |
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| Appearance: | Orange solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Co-activation of WT1 and AP-1 proteins on WT1 gene promoter to induce WT1 gene expression in K562 cells: S. Anuchapreeda, et al.; Cell Signal.
53, 339 (2018),
Abstract;
Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza: B.Y. Kang, et al.; Immunopharmacology
49, 355 (2000),
Abstract;
S. Park, et al.; Bull. Korean Chem. Soc. 20, 925 (1999),
Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3: H.J. Sung, et al.; Exp. Mol. Med.
31, 174 (1999),
Abstract;
