Replaces Prod. #: ALX-380-023
Antitumor antibiotic. DNA crosslinking and damaging agent. Inhibitor of DNA synthesis, nuclear division and cancer cells. DNA intercalating agent. Induces apoptosis in a variety of cells via a p53-dependent pathway.
Product Details
Formula: | C15H18N4O5 |
|
MW: | 334.3 |
|
CAS: | 50-07-7 |
|
MI: | 14: 6215 |
|
RTECS: | CN0700000 |
|
Purity: | ≥95% (HPLC) |
|
Appearance: | Blue-violet solid. |
|
Solubility: | Soluble in water (1mg/ml, warm), 100% ethanol (1mg/ml, warm), DMSO (15mg/ml) or methanol. |
|
Shipping: | Blue Ice |
|
Long Term Storage: | -20°C |
|
Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Stock solutions in water or ethanol are stable for up to 1 week at -20°C. Stock solutions in DMSO are stable for up to 1 month at -20°C. |
|
Handling: | Protect from light. |
|
Technical Info/Product Notes: | Note: Product is not sterile. |
|
Regulatory Status: | RUO - Research Use Only |
|
Please mouse over
Product Literature References
Membrane-bound p35 Subunit of IL-12 on Tumor Cells is Functionally Equivalent to Membrane-bound Heterodimeric Single Chain IL-12 for Induction of Anti-tumor Immunity : H.J. Kim, et al.; Immune Netw.
16, 305 (2016),
Application(s): Proliferation of ConA-activated splenocytes,
Abstract;
Full Text
A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial associated necrosis in breast cancer: A. Bastian, et al.; J. Pharmacol. Exp. Ther.
353, 392 (2015),
Application(s): Assay,
Abstract;
Full Text
Keratinocyte nicotinic acetylcholine receptor activation modulates early TLR2-mediated wound healing responses: M. Kishibe, et al.; Int. Immunopharmacol.
29, 63 (2015),
Application(s): Cell Culture,
Abstract;
PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype: S. Duan, et al.0; Nat. Commun.
6, 10068 (2015),
Application(s): Cell culture, MMC selectively killed PTEN-deficient NSCs,
Abstract;
The novel function of OCT4B isoform-265 in genotoxic stress: Y. Gao, et al.; Stem Cells
30, 665 (2012),
Abstract;
Full Text
Activation of the S phase DNA damage checkpoint by mitomycin C: E. Mladenov, et al.; J. Cell. Physiol.
211, 468 (2007),
Abstract;
Re-evaluation of tumor-specific cytotoxicity of mitomycin C, bleomycin and peplomycin: M. Sasaki, et al.; Anticancer Res.
26, 3373 (2006),
Abstract;
DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling: A.R. Tee & C.G. Proud; Oncogene
19, 3021 (2000),
Abstract;
Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95- independent manner in human gastric adenocarcinoma cells: I.C. Park, et al.; Cancer Lett.
158, 125 (2000),
Abstract;
Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis: C.T. Hsueh, et al.; Cancer Chemother. Pharmacol.
45, 389 (2000),
Abstract;
Mitomycins: J. Verweij, et al.; Cancer Chemother. Biol. Response Modif.
18, 46 (1999),
Abstract;
p53-dependent and p53-independent activation of apoptosis in mammary epithelial cells reveals a survival function of EGF and insulin: G.R. Merlo, et al.; J. Cell Biol.
128, 1185 (1995),
Abstract;
Elevated DT-diaphorase activity and messenger RNA content in human non- small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cl: A.M. Malkinson, et al.; Cancer Res.
52, 4752 (1992),
Abstract;
Genetic evidence for an activator required for induction of pectin lyase in Erwinia carotovora subsp. carotovora by DNA-damaging agents: J.L. McEvoy, et al.; J. Bacteriol.
174, 5471 (1992),
Abstract;
Polyoxyethylene-modified superoxide dismutase reduces side effects of adriamycin and mitomycin C: S. Kawasaki, et al.; J. Cancer Res.
83, 899 (1992),
Abstract;
DNA sequence specificity of mitomycin cross-linking: S.P. Teng, et al.; Biochemistry
28, 3901 (1989),
Abstract;
The chemistry of DNA modification by antitumor antibiotics: J.F. Fisher & P.A. Aristoff; Prog. Drug Res.
32, 411 (1988),
Abstract;
Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA: M. Tomasz, et al.; Science
235, 1204 (1987),
Abstract;
Sequence-specific DNA damage induced by reduced mitomycin C and 7-N-(p- hydroxyphenyl)mitomycin C: K. Ueda and T. Komano; Nucl. Acids Res.
12, 6673 (1984),
Abstract;
Revised absolute configuration of mitomycin C. X-ray analysis of 1-N-(p-bromobenzoyl)mitomycin C: K. Shirahata & N. Hirayama; JACS 105, 7199 (1983),
Mitomycin C. Current Status and New Developments: S.K. Carter & S.T. Crooke ; Academic Press, New York (1979), (Book),
Mitomycin, a new antibiotic from Streptomyces. I: T. Hata, et al.; J. Antibiot. (Tokyo)
9, 141 (1956),
Abstract;