Replaces Prod. #: ALX-270-209
Antitumor reagent. Topoisomerase II inhibitor. Induces apoptosis by FasL. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells.
Product Details
Alternative Name: | 4-Desmethylepipodophyllotoxin 9-(4,6-O-ethylidene)-β-D-glucopyranoside, VP-16-213 |
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Formula: | C29H32O13 |
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MW: | 588.6 |
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Source: | Semisynthetic derivative of podophyllotoxin. |
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CAS: | 33419-42-0 |
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MI: | 14: 3886 |
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RTECS: | KC0190000 |
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Purity: | ≥95% (HPLC) |
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Appearance: | White to off-white powder. |
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Solubility: | Soluble in DMSO, dimethyl formamide, ethyl ether or chloroform:methanol (1:1); slightly soluble in methanol or acetone; insoluble in water. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | Ambient |
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Use/Stability: | Store solutions in DMSO at 4°C. For long term storage prepare aliquots and store at -20°C. |
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Handling: | Protect from light and moisture. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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