Adapalene is a stable analog of retinoic acid and acts selectively as an agonist at RARβ and RARγ. It inhibits proliferation and induces apoptosis in colorectal cancer cells. Its unique pharmacological properties make it superior to other retinoids for the treatment of acne.
Product Details
| Alternative Name: | 6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid |
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| Formula: | C19H34O3 |
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| MW: | 412.5 |
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| CAS: | 106685-40-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (3 mg/mL) or DMF (6 mg/mL). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at-20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro: M. Ocker, et al.; Int. J. Cancer
107, 453 (2003),
Abstract;
Adapalene: an update on newer comparative studies between the various retinoids: L. E. Milikan, et al.; Int. J. Dermatoil.
39, 784 (2000),
Abstract;
Pharmacology of adapalene: S. Michel, et al.; Br. J. Dermatol.
139, 52 (1998),
Abstract;
