L-Buthionine-sulfoximine (BSO) induces oxidative stress in cells by irreversibly inhibiting γ-glutamylcysteine synthetase, an essential enzyme for the synthesis of glutathione.
Product Details
| Alternative Name: | BSO |
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| Formula: | C8H18N2O3S |
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| MW: | 222.3 |
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| CAS: | 83730-53-4 |
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| Purity: | ≥97% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans: B.A. Martinez, et al.; Cell Death Dis.
6, e1908 (2015),
Application(s): Cell Culture,
Abstract;
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Manganese superoxide dismutase knock-down in 3T3-L1 preadipocytes impairs subsequent adipogenesis: S. Krautbauer, et al.; Mol. Cell. Biochem.
393, 69 (2014),
Application(s): Treatment of 3T3-L1 cells in culture,
Abstract;
Glutathione depletion by buthionine sulfoximine induces DNA deletions in mice: R. H. Schiestl & R. Reliene; Carcinogenesis
27, 240 (2006),
Abstract;
