The lazaroid U-83836E prevents hydrogen peroxide-induced F2 isoprostane production in renal proximal tubular cells and reduces secondary brain injury in a rabbit model of cryogenic trauma.
Product Details
| Alternative Name: | (-)-2-((4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol . 2HCl |
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| Formula: | C30H44N6O2 . 2HCl |
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| MW: | 593.6 |
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| CAS: | 122003-11-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (30 mg/ml) or ethanol (>50 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Propofol Ameliorates Calpain-induced Collapsin Response Mediator Protein-2 Proteolysis in Traumatic Brain Injury in Rats: Y. Yu, et al.; Chin. Med. J. (Engl).
128, 919 (2015),
Application(s): Injection in rat,
Abstract;
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Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol.
6, 1300 (1995),
Abstract;
Full Text
Lazaroids and deferoxamine attenuate the intracellular effects of oxyhaemoglobin in vascular smooth muscle: B. Vollrath, et al.; Cardiovasc. Res.
30, 619 (1995),
Abstract;
U83836E reduces secondary brain injury in a rabbit model of cryogenic trauma: J. T. Wilson, et al.; J. Trauma
39, 473 (1995),
Abstract;
