A potent and selective 15-lipoxygenase inhibitor which lacks significant nonspecific antioxidant properties. It suppresses atherogenesis and limits atherosclerotic lesion development in the rabbit. It reduces oxidant stress-induced apoptosis in endothelial cells and inhibits proliferation in 15-LO overexpressing PC3 cells.
Product Details
| Formula: | C15H11NS |
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| MW: | 237.3 |
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| CAS: | 4079-26-9 |
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| Purity: | ≥98% (HPLC) |
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| Solubility: | Soluble in DMSO (50mg/mL) and ethanol (10mg/mL). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Solutions should be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation: X. Wang, et al.; PLoS One
12, e1005803 (2016),
Application(s): Pharmacological inhibition of lipoxygenase enzymes, inflammation pathway,
Abstract;
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Metabolites derived from omega-3 polyunsaturated fatty acids are important for cardioprotection: K. Gilbert, et al.; Eur. J. Pharmacol.
769, 147 (2015),
Application(s): Cell culture,
Abstract;
Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells: L.M. Sordillo, et al.; Prostaglandins Other Lipid Mediat.
76, 19 (2005),
Abstract;
Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis: U.P. Kelavkar, et al.; Carcinogenesis
22, 1765 (2001),
Abstract;
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A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit: T.M. Bocan, et al.; Atherosclerosis
136, 203 (1998),
Abstract;
Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties: S.M. Sendobry, et al.; Br. J. Pharmacol.
120, 1199 (1997),
Abstract;
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