Replaces Prod. #: ALX-550-519
Selectively inhibits monoacylglycerol (MAG) lipase (IC50=28µM) via a noncompetitive mechanism. Does not inhibit FAAH, DAG lipase or COX-2. URB-602 selectively raises levels of 2-arachidonoylglycerol with no change in anandamide concentrationsin cells and tissues. In the same way anandamide levels were markely elevated by the FAAH inhibitor URB597 at 1µM.
Product Details
| Alternative Name: | Biphenyl-3-yl carbamic acid cyclohexyl ester |
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| Formula: | C19H21NO2 |
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| MW: | 295.4 |
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| CAS: | 565460-15-3 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| MeltingPoint: | 122-123ºC |
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| Solubility: | Soluble in DMSO (30 mg/ml) or ethanol (5 mg/ml warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
An endocannabinoid mechanism for stress-induced analgesia: A.G. Hohmann et al.; Nature
435, 1108 (2005),
Abstract;
