Wedelolactone is a naturally occuring furanocoumarin isolated from Eclipta prostrata, an herbal medicine used to treat septic shock in traditional Chinese medicine. It inhibits the IκB kinase (IKK) complex and supresses LPS-induced caspase-11 expression in LPS-treated BALB 3T3 cells (IC50=35µM)
Product Details
| Alternative Name: | 7-Methoxy-5,11,12-trihydroxycoumestan |
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| Formula: | C16H10O7 |
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| MW: | 314.2 |
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| CAS: | 524-12-9 |
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| Purity: | ≥96% (HPLC) |
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| Appearance: | Yellow-green solid |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex: M. Kobori, et al.; Cell Death Differ.
11, 123 (2004),
Abstract;
