Replaces Prod. #: ALX-270-220
An irreversible inhibitor of cytokine-inducible IκBα phosphorylation (IC50=10 µM). In intact HUVECs it inhibits TNFα-induced phosphorylation and degradation of IκBα without affecting constitutive phosphorylation. Inhibition of IκBα phosphorylation and degradation results in the inactivation of NF-κB and NF-κB-dependent expression of endothelial-leukocyte adhesion molecules, E-selectin, VCAM-1 and ICAM-1. BAY 11-7085 displayed potent anti-inflammatory activity in the rat carrageenan paw edema assay and adjuvant arthritis model.
Product Details
| Formula: | C13H15NO2S |
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| MW: | 249.3 |
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| CAS: | 196309-76-9 |
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| Purity: | ≥99% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Protect from light. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis: L.C. Chang, et al.; Cancer Lett.
416, 124 (2018),
Abstract;
Drug-perturbation-based stratification of blood cancer: S. Dietrich, et al.; J. Clin. Invest.
128, 427 (2017),
Abstract;
Full Text
Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress: K.S. Lee, et al.; Thorax
71, 52 (2015),
Application(s): Cell culture ,
Abstract;
Full Text
TGF-β Negatively Regulates CXCL1 Chemokine Expression in Mammary Fibroblasts through Enhancement of Smad2/3 and Suppression of HGF/c-Met Signaling Mechanisms: W.B. Fang, et al.; PLoS One
10, e0135063 (2015),
Abstract;
Full Text
In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas: P.A. Robe, et al.; Clin. Cancer Res.
10, 5595 (2004),
Abstract;
Neuronal injury-induced expression and release of apolipoprotein E in mixed neuron/glia co-cultures: nuclear factor kappaB inhibitors reduce basal and lesion-induced secretion of apolipoprotein E: V. Petegnief, et al.; Neuroscience
104, 223 (2001),
Abstract;
Pharmacologic interference with NF-kappaB activation attenuates central nervous system complications in experimental Pneumococcal meningitis: U. Koedel, et al.; J. Infect. Dis.
182, 1437 (2000),
Abstract;
Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo: J.W. Pierce, et al.; J. Biol. Chem.
272, 21096 (1997),
Abstract;
