Replaces Prod. #: ALX-270-181
Damnacanthal is a potent and selective inhibitor of p56lck tyrosine kinase. It inhibits p56lck autophosphorylation (IC50=17 nM) as well as phosphorylation of exogenous substrates (IC50=620 nM) in cell-free assays. Damnacanthal shows a 10-fold selectivity for p56lck over PKA and PKC and 40-fold selectivity over four receptor tyrosine kinases as well as 7–20-fold selectivity over the homologous enzymes p60src and p59fyn.
Product Details
| Alternative Name: | 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde |
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| Formula: | C16H10O5 |
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| MW: | 282.2 |
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| CAS: | 477-84-9 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determinedy by NMR. |
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| Appearance: | Pale orange solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity: C.R. Faltynek, et al.; Biochemistry
34, 12404 (1995),
Abstract;
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia: T. Hiramatsu, et al.; Cancer Lett.
73, 161 (1993),
Abstract;
Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum: K. Koumaglo, et al.; Planta Med.
58, 533 (1992),
Abstract;
Anthraquinone and anthrone series—XXIII: The non-identity of 1:3:8-trihydroxy-2-hydroxymethyl-anthraquinone with versicolorin and a synthesis of damnacanthol and damnacanthal: N.R. Ayyangar, et al.; Tetrahedron 6, 331 (1959),
Chemistry of Damnacanthus Genus. I - The Anthraquinone Coloring Matter from Damnacanthus major, D. major var. parvifolius, and D. indicus var. microphyllus. (1): S. Nonomura; Yakugaku Zasshi
75, 219 (1955), (Article in Japanese),
Abstract;
