Replaces Prod. #: ALX-270-031
AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.
Product Details
| Alternative Name: | 3-Hydroxy-4-nitrobenzylidenemalononitrile |
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| Formula: | C10H5N3O3 |
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| MW: | 215.2 |
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| CAS: | 118409-62-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Yellow solid. |
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| MeltingPoint: | 181-182°C |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Store tightly sealed in the dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Stage-Specific Expression of TNFα Regulates Bad/Bid-Mediated Apoptosis and RIP1/ROS-Mediated Secondary Necrosis in Birnavirus-Infected Fish Cells: W. Wang, et al.; PLoS One
6, e16740 (2011),
Abstract;
Full Text
The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat: L. Dugo, et al.; Intensive Care Med.
28, 775 (2002),
Abstract;
The Tyrosine Kinase Inhibitor Tyrphostin AG 126 Reduces the Development of Colitis in the Rat: S. Cuzzocrea, et al.; Lab. Invest.
80, 1439 (2000),
Abstract;
Full Text
The Tyrosine Kinase Inhibitor Tyrphostin AG126 Reduces the Development of Acute and Chronic Inflammation: S. Cuzzocrea, et al.; Am. J. Pathol.
157, 145 (2000),
Abstract;
Full Text
Tyrosine kinase inhibition: an approach to drug development: A. Levitzki & A. Gazit; Science
267, 1782 (1995),
Abstract;
Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors: A. Novogrodsky, et al.; Science
264, 1319 (1994),
Abstract;
Protein-tyrosine kinase activity tightly associated with human type II Fc gamma receptors: G. Sarmay, et al.; PNAS
91, 4140 (1994),
Abstract;
Receptor-mediated activation of human B lymphocytes in a nonphosphotyrosine-dependent manner: C.M. Roifman & G. Wang; J. Immunol.
149, 1179 (1992),
Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem.
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Abstract;
