Replaces Prod. #: ALX-270-084
Selective inhibitor of MLC kinase (Ki=3.8 µM). Inhibits insulin-stimulated 2-deoxyglucose transport and PP-1 activation in adipocytes, possibly via an effect on MAP kinase or its activation. Useful PKB inhibitor (IC50=10-50 µM). Also known to inhibit PKA (IC50=20 µM) and S6 kinase (IC50=50 µM). Does not inhibit PI 3-kinase.
Product Details
| Alternative Name: | 1-(5-Chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine . HCl |
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| Formula: | C15H17N2O2SCl . HCl |
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| MW: | 361.3 |
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| CAS: | 105637-50-1 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (10mg/ml) and ethanol/water (1:1, 10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
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Abstract;
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