Replaces Prod. #: ALX-300-078
Inhibits protein kinase C activation by diacylglycerols. Stimulates HL-60 cell differentiation. Biosynthetic precursor of PAF via remodeling and retroconversion/de novo routes. Induces delayed aggregation of rabbit platelets. Mitogenic for smooth muscle cells.
Product Details
| Formula: | C21H42O4 |
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| MW: | 358.6 |
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| CAS: | 77133-35-8 |
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| Purity: | ≥95% (TLC) |
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| Appearance: | Waxy solid. |
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| Solubility: | Soluble in 100% ethanol or acetone. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 6 months at -20°C. |
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| Handling: | Hygroscopic. Protect from moisture. |
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| Technical Info/Product Notes: | Avoid acidic or basic conditions. Note: Product is not sterile |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Is there an interplay between the SARS-CoV-2 spike protein and Platelet-Activating factor?: S. Antonopoulou, et al.; Biofactors
48, 1271 (2022),
Abstract;
Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions: I.C. Vlachogianni, et al.; Prostaglandins Other Lipid Mediat.
121, 176 (2015),
Abstract;
Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets: T.C. Lee, et al.; J. Biol. Chem.
265, 9181 (1990),
Abstract;
1-O-alkyl-2-acetyl-sn-glycerol: a platelet-activating factor metabolite with biological activity in vascular smooth muscle cells: L.L. Stoll, et al.; Cell Regul.
1, 13 (1989),
Abstract;
Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols: L.W. Daniel, et al.; BBRC
151, 291 (1988),
Abstract;
1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells: M.J.C. McNamara, et al.; BBRC
122, 824 (1984),
Abstract;
A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn- glycerols, a precursor of platelet activating factor: M.L. Blank, et al.; BBRC
118, 344 (1984),
Abstract;
Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets: M.L. Blank, et al.; BBRC
124, 156 (1984),
Abstract;
Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor: K. Satouchi, et al.; Arch. Biochem. Biophys.
234, 318 (1984),
Abstract;
