Replaces Prod. #: ALX-385-022
Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64µM for 12-LO and 1.6µM for 15-LO). Inhibits leukotriene biosynthesis (at higher concentrations) and release of lysosomal enzymes. Inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (POP/PREP)(IC50=36µM).
Product Details
| Alternative Name: | 5,6,7-Trihydroxyflavone |
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| Formula: | C15H10O5 |
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| MW: | 270.2 |
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| CAS: | 491-67-8 |
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| MI: | 14: 942 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Yellow to yellow-green crystalline powder. |
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| Solubility: | Soluble in DMSO, acetone, 100% ethanol or methanol; almost insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Subject to oxidation. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Application(s): Treatment onf SW480 cells in culture,
Abstract;
Mediatory roles of leukotriene B4 receptors in LPS-induced endotoxic shock: S.Y. Kwon, et al.; Sci. Rep.
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Abstract;
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Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor: T. Tarrago, et al.; Bioorg. Med. Chem.
16, 7516 (2008),
Abstract;
Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile: Y. Chang, et al.; Neurosci. Lett.
441, 16 (2008),
Abstract;
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression: H.Y. Lin, et al.; Biochim. Biophys. Acta
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Abstract;
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases: J. D. Deschamps, et al.; Bioorg. Med. Chem.
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Abstract;
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells: H.Z. Lee, et al.; Anticancer Res.
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Abstract;
Biological properties of baicalein in cardiovascular system: Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord.
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Abstract;
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes: Y.C. Shen, et al.; Eur. J. Pharmacol.
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Abstract;
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules: S.L. Hsu, et al.; Eur. J. Pharmacol.
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Abstract;
Protective effects of baicalein against cell damage by reactive oxygen species: D. Gao, et al.; Chem. Pharm. Bull. (Tokyo)
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Abstract;
Arachidonic acid metabolites in bFGF-, PDGF-, and serum-stimulated vascular cell growth: S.M. Dethlefsen, et al.; Exp. Cell Res.
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Abstract;
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells: H.C. Huang, et al.; Eur. J. Pharmacol.
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Abstract;
Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots: I.G. Butenko, et al.; Agents Actions
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Abstract;
Biliary excretion of metabolites of baicalin and baicalein in rats: K. Abe, et al.; Chem. Pharm. Bull.
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Abstract;
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone: K. Ono, et al.; BBRC
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Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells: J.L. Nadler, et al.; J. Clin. Invest.
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Abstract;
Selective inhibition of platelet lipoxygenase by baicalein: K. Sekiya & H. Okuda; BBRC
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Abstract;
