Synthesis via enzymatic and nonenzymatic hydrolysis of LTA4. Induces contraction of guinea pig lung parenchymal strips. Partial agonist at LTD4 receptors. Potent inhibitor of LTB4 induced neutrophil migration (IC50 = 8nM).
Product Details
| Alternative Name: | 5(S),6(R)-DiHETE |
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| Formula: | C20H32O4 |
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| MW: | 336.5 |
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| CAS: | 82948-88-7 |
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| Formulation: | Oil dissolved in ethanol. |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | Colorless liquid. |
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| Shipping: | Dry Ice - Dangerous Good |
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| Long Term Storage: | -80°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Comparative biological activities of the four synthetic (5,6)-dihete isomers: A. Muller, et al.; Prostaglandins
38, 635 (1989),
Abstract;
Comparative activity of natural mono-, di- and tri-hydroxy derivatives of arachidonic acid on guinea-pig lungs: myotropic effect and stimulation of cyclooxygenase activity: P. Sirois, et al.; Prostaglandins
24, 405 (1982),
Abstract;
