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1-Oleoyl-2-acetyl-sn-glycerol

PKC activator



BML-DG125-0010	10 mg	153.00 USD

BML-DG125-0050	50 mg	621.00 USD
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Replaces Prod. #: ALX-300-300

In vitro potent activator of protein kinase C (PKC). Stimulator of secretion and aggregation in blood platelets. Stimulates formation of actin nucleation sites. Stimulation of pp60c-src phosphorylation in EBV transformed B-cells, 470μM.

Product Details

Alternative Name:	OAG

Formula:	C₂₃H₄₂O₅

MW:	398.6

Source:	Synthetic.

CAS:	86390-77-4

Purity:	≥95% (TLC)

Appearance:	Colorless oil or waxy solid.

Solubility:	Soluble in DMSO or ethanol.

Shipping:	Blue Ice

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

New patterns of diacylglycerol metabolism in intact cells: J. Florin-Christensen; Biochem. J. 289, 783 (1993), Abstract;

Ca2+ and partly GTP gamma S-dependent particulate phospholipase C hydrolyzing phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate is inhibited by diacyl(acyl-acetyl) glycerols: E.W. Haeffner & U. Wittmann; J. Lipid Mediat. 5, 237 (1992), Abstract;

Diacylglycerol-stimulated formation of actin nucleation sites at plasma membranes: A. Shariff & E.J. Luna; Science 256, 245 (1992), Abstract;

Opposite effects of angiotensin II and the protein kinase C activator OAG on cardiac Na+ channels: I. Benz, et al.; J. Membr. Biol. 130, 183 (1992), Abstract;

Structural requirements of diacylglycerols for binding and activating phospholipid-dependent, Ca++-sensitive protein kinase: D.E. Kerr, et al.; Biochem. Biophys. Res. Commun. 148, 776 (1987), Abstract;

A possible role of protein kinase C in signal-induced lysosomal enzyme release: N. Kajikawa, et al.; BBRC 116, 743 (1983), Abstract;

Ca2+ and protein kinase C: Two synergistic cellular signals: B. Michell; Trends Biochem. Sci. 8, 263 (1983), (Review),

Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets: T.J. Rink, et al.; Nature 305, 317 (1983), Abstract;

Phorbol ester and diacylglycerol induce protein phosphorylation at tyrosine: T. Gilmore & G.S. Martin; Nature 306, 487 (1983), Abstract;

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation: K. Kaibuchi, et al.; J. Biol. Chem. 258, 6701 (1983), Abstract; Full Text

Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation: K. Kaibuchi, et al.; Cell Calcium 3, 323 (1982), Abstract;

Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase: T. Mori, et al.; J. Biochem. 91, 427 (1982), Abstract;