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Clozapine

Dopamine receptor and serotonin receptor antagonist



BML-D107-0050	50 mg	85.00 USD

BML-D107-0500	500 mg	505.00 USD
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Replaces Prod. #: ALX-550-088

Dopamine D₄ and D₂ receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (K_i<20nM). Atypical neuroleptic agent. Antagonist at 5HT_2A, 5HT_2C, 5HT₃, 5HT₆ and 5HT₇ receptors.

Product Details

Alternative Name:	8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine

Formula:	C₁₈H₁₉ClN₄

MW:	326.8

CAS:	5786-21-0

MI:	14: 2423

RTECS:	HP1750000

Purity:	≥99% (HPLC)

Identity:	Determined by IR.

Appearance:	Yellow crystalline powder.

Solubility:	Soluble in DMSO (30mg/ml) or dilute aqueous acid.

Shipping:	Ambient Temperature

Long Term Storage:	+4°C

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), Abstract; Full Text

D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs: B.L. Roth, et al.; Psychopharmacology 120, 365 (1995), Abstract;

Interaction of clozapine with the histamine H3 receptor in rat brain: A.A. Rodrigues, et al.; Br. J. Pharmacol. 114, 1523 (1995), Abstract;

Role of serotonin in the action of atypical antipsychotic drugs: H.Y. Meltzer; Clin. Neurosci. 3, 64 (1995), Abstract;

5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 255, 91 (1994), Abstract;

Clozapine is a potent and selective muscarinic M4 receptor agonist: S.H. Zorn, et al.; Eur. J. Pharmacol. 269, R1 (1994), Abstract;

Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 245, 179 (1993), Abstract;

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine: H.H. Van Tol, et al.; Nature 350, 610 (1991), Abstract;

The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine: B.A. Ellenbroek, et al.; Eur. J. Pharmacol. 196, 103 (1991), Abstract;

Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites: H. Canton, et al.; Eur. J. Pharmacol. 191, 93 (1990), Abstract;