Replaces Prod. #: ALX-380-036
Inhibits mitochondrial ATPases (F1F0). Stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Induces autophagy in the IPLB-LdFB insect cell line.
Product Details
Formula: | C45H74O11 |
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MW: | 791.1 |
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CAS: | 579-13-5 |
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MI: | 14: 6833 |
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RTECS: | RK3328000 |
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Purity: | ≥97% (HPLC, TLC) |
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Appearance: | White solid. |
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Solubility: | Soluble in DMSO (300mg/ml), 100% ethanol (200mg/ml) or acetone (800mg/ml). |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Functional characterization of two variants of mitochondrial topoisomerase TOP1MT that impact regulation of the mitochondrial genome: I.A. Khatib, et al.; J. Biol. Chem.
298, 102420 (2022),
Abstract;
Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells: W.F. Alpaugh, et al.; Cells
10, 2265 (2021),
Abstract;
Unique metabolic phenotype and its transition during maturation of juvenile male germ cells: A.L. Voigt, et al.; FASEB J.
35, 21513 (2021),
Abstract;
Oligomycin A induces autophagy in the IPLB-LdFB insect cell line: G. Tettamanti, et al.; Cell Tissue Res.
326, 179 (2006),
Abstract;
Mitochondria-targeting drug oligomycin blocked P-glycoprotein activity and triggered apoptosis in doxorubicin-resistant HepG2 cells: Y.C. Li, et al.; Chemotherapy
50, 55 (2004),
Abstract;
Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis: L.A. Shchepina, et al.; Oncogene
21, 8149 (2002),
Abstract;
The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin: M.E. Fitch, et al.; Cell Death Differ.
7, 338 (2000),
Abstract;
Acidification of rat liver lysosomes: quantitation and comparison with endosomes: R.W. Van Dyke; Am. J. Physiol.
265, C901 (1993),
Abstract;
Inhibitors of the ATP synthethase system: P.E. Linnett & R.B. Beechey; Methods Enzymol.
55, 472 (1979),
Abstract;