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NPPB

Cl^- channel blocker



BML-CM100-0010	10 mg	65.00 USD

BML-CM100-0050	50 mg	295.00 USD
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Replaces Prod. #: ALX-550-279

A potent chloride channel blocker (IC₅₀=0.1-100 µM depending on channel subtype and assay method). Inhibits cyclooxygenase (COX; IC₅₀=8 µM). Evidence of mitochondrial uncoupling in mouse peritoneal macrophages, due to protonophore activity.

Product Details

Alternative Name:	5-Nitro-2-(3’-phenylpropyl-amino)benzoic acid

Formula:	C₁₆H₁₆N₂O₄

MW:	300.3

CAS:	107254-86-4

Purity:	≥98% (HPLC)

Appearance:	Yellow solid.

Solubility:	Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml; warm).

Shipping:	Ambient Temperature

Long Term Storage:	Ambient

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Inhibition of Regulatory Volume Decrease Enhances the Cytocidal Effect of Hypotonic Shock in Hepatocellular Carcinoma: M. Kudou, et al.; J. Cancer 7, 1524 (2016), Application(s): Cell culture, human HCC cell lines, Abstract; Full Text

The adenosine A2B receptor is involved in anion secretion in human pancreatic duct Capan-1 epithelial cells: M. Hayashi, et al.; Pflugers Arch. 468, 1171 (2016), Application(s): Cell culture, Abstract; Full Text

Different types of blockers of the intermediate-conductance outwardly rectifying chloride channel in epithelia: M. Tilmann, et al.; Pflugers Arch. 418, 556 (1991), Abstract;

Effects of NPPB (5-nitro-2-(3-phenylpropylamino)benzoic acid) on chloride transport in intestinal tissues and the T84 cell line: D.J. Keeling, et al.; Biochim. Biophys. Acta 1115, 42 (1991), Abstract;

Actions of the Cl- channel blocker NPPB on absorptive and secretory transport processes of Na+ and Cl- in rat descending colon: M. Diener & W. Rummel; Acta Physiol. Scand. 137, 215 (1989), Abstract;

Inhibition of prostaglandin E2 synthesis by a blocker of epithelial chloride channels: W. Breuer & K.L. Skorecki; Biochem. Biophys. Res. Commun. 163, 398 (1989), Abstract;

Cl(-)-channel blockers in the thick ascending limb of the loop of Henle. Structure activity relationship: P. Wangemann, et al.; Pflugers Arch. 407, S128 (1986), Abstract;