Replaces Prod. #: ALX-430-107
Induces apoptosis but does not inhibit cyclooxygenase. Inhibits growth and induces apoptosis in human cancer cell lines. Metabolite of Sulindac (Prod. No. ALX-430-105).
Product Details
| Alternative Name: | Z-5-Fluoro-2-methyl-1-[p-(methyl-sulfonyl)benzylidene]indene-3-acetic acid |
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| Formula: | C20H17FO4S |
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| MW: | 372.4 |
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| CAS: | 59864-04-9 |
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| Purity: | ≥94% (HPLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (3mg/ml, warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Sulindac inhibits activation of the NF-kappaB pathway: Y. Yamamoto, et al.; J. Biol. Chem.
274, 27307 (1999),
Abstract;
Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis: G.A. Piazza, et al.; Cancer Res.
55, 3110 (1995),
Abstract;
