Integrin αvβ3 antagonist. Inhibits cell adhesion events mediated by αvβ3. Inhibits angiogenesis. Induces rapid regression of histologically distinct human tumors. Induces apoptosis of angiogenic blood vessels.
Product Details
| Sequence: | Cyclo[Arg-Gly-Asp-D-Phe-Val] |
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| Formula: | C26H38N8O7 . HOAc . 0.5H2O |
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| MW: | 643.7 |
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| CAS: | 137813-35-5 |
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| Purity: | ≥98% |
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| Appearance: | Lyophilized solid. |
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| Solubility: | Soluble in DMSO (5 mg/ml) and PBS (1 mg/350μl). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
MAdCAM-1 Costimulates T Cells through Integrin α 4 β 7 to Cause Gene Expression Events Resembling Costimulation through CD28: H.A. DeBerg, et al.; Immunohorizons
6, 211 (2022),
Abstract;
Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling: D.M. Cedano Prieto, et al.; PLoS One
12, e0184285 (2017),
Application(s): Inhibition of beta3-CHO cell binding to IGF2,
Abstract;
Full Text
Testing the efficacy of Contrast Enhanced Ultrasound in detecting transplant rejection using a murine model of heart transplantation: K. Fischer, et al.; Am. J. Transplant.
17, 1791 (2017),
Abstract;
Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels: P.C. Brooks, et al.; Cell
79, 1157 (1994),
Abstract;
Arg-Gly-Asp constrained within cyclic pentapeptides. Strong and selective inhibitors of cell adhesion to vitronectin and laminin fragment P1: M. Aumailley, et al.; FEBS Lett.
291, 50 (1991),
Abstract;
