Replaces Prod. #: ALX-380-278
Aminocyclitol antibiotic active against Gram-negative and Gram-positive bacteria (Gonnococcus only). In clinical use for gonorrhea. Inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation. Binds to the 30S subunit of bacterial ribosomes. Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin.
Product Details
| Alternative Name: | Spectinomycin . dihydrochloride . pentahydrate, U-18409AE |
| |
| Formula: | C14H24N2O7 . 2HCl . 5H2O |
| |
| MW: | 495.3 |
| |
| CAS: | 22189-32-8 |
| |
| MI: | 14: 8739 |
| |
| RTECS: | WG7400000 |
| |
| Purity: | ≥ 600µg/mg (potency) |
| |
| Appearance: | White to off-white powder. |
| |
| Solubility: | Soluble in water (50mg/ml). |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | +4°C |
| |
| Use/Stability: | Stable for up to 1 year after receipt when stored at +4°C. Stock solutions are stable for up to 3 months at -20°C. |
| |
| Technical Info/Product Notes: | Note: Product is not sterile. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
In vivo selection of spectinomycin-binding RNAs: J.M. Zimmerman & L.J. Maher; Nucl. Acids Res.
30, 5425 (2002),
Abstract;
Full Text
Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues: P.R. Thompson, et al.; J. Biol. Chem.
273, 14788 (1998),
Abstract;
Full Text
Isolation of a gene encoding a novel spectinomycin phosphotransferase from Legionella pneumophila: Antimicrob. Agents Chemother.; T.M. Suter, et al.
41, 1385 (1997),
Abstract;
Full Text
The selection in vivo and characterization of an RNA recognition motif for spectinomycin: G. Thom & C.D. Prescott; Bioorg. Med. Chem.
5, 1081 (1997),
Abstract;
Spectinomycin versus tetracycline for the treatment of gonorrhea: W.W. Karney, et al.; N. Engl. J. Med.
296, 889 (1977),
Abstract;
New antibiotics: epicillin, minocycline and spectinomycin a summary of their antibacterial activity, pharmacokinetic properties and therapeutic efficacy: R.N. Brogden & G.S. Avery; Drugs
3, 314 (1972),
Abstract;
Sensitivity and Resistance to Spectinomycin in Escherichia coli: P. Anderson; J. Bacteriol.
100, 939 (1969),
Abstract;
Full Text
