Replaces Prod. #: ALX-480-083
A puromycin analog which does not inhibit protein synthesis or induce apoptosis. It is a glomerular epithelial cell toxin which may be used to induce nephropathy in laboratory animals.
Product Details
| Alternative Name: | 3'-Amino-3'-Deoxy-N,N-dimethyladenosine |
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| Formula: | C12H16N6O3 |
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| MW: | 294.3 |
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| CAS: | 58-60-6 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| MeltingPoint: | 222-223°C |
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| Solubility: | Soluble in water (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Puromycin aminonucleoside suppresses integrin expression in cultured glomerular epithelial cells: U. Krishnamurti et al.; J. Am. Soc. Nephrol.
12, 758 (2001),
Abstract;
Dietary vitamin E supplementation ameliorates renal injury in chronic puromycin aminonucleoside nephropathy: H. Trachtman et al.; J. Am. Soc. Nephrol.
5, 1811 (1995),
Abstract;
Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis: S.C. Chow et al.; Exp Cell Res
216, 1995 (1995),
Abstract;
