The SCREEN-WELL® Kinase Inhibitor Library contains 80 known kinase inhibitors of well-defined activity. Inhibitors are supplied dissolved in DMSO at 10 mM and aliquoted into deep-well plates at either 100 or 500 microliters per well. The library is an ideal tool for chemical genomics, assay development and other pharmacological applications. Includes inhibitors of these important kinases: Insulin/IGF Receptors, PI 3-Kinase, CaM Kinase II, JAK, PKA, CDK, JNK, PKC, CKI II, MAPK, RAF, EGFR, MEK, SAPK, GSK, MLCK, Src-family, IKK, PDGFR, VEGFR and many more.
Product Details
| Applications: | HTS
|
| |
| Contents: | 80 compounds including inhibitors of these important kinases: BTK, CaM Kinase, CDK, CKI & II, EGFR, GSK, IKK, Insulin receptor, JAK, JNK, MAPK, MEK, MLCK, PI 3-Kinase, PDGFR, PKA, PKC, RAF, SAPK, Src-family, VEGFR, and more. |
| |
| Quantity: | 100µl or 500µl per well |
| |
| Formulation: | DMSO solutions. |
| |
| Concentration: | 10mM |
| |
| Use/Stability: | Stable for at least one year from the date of receipt when stored at -80°C. |
| |
| Shipping: | Dry Ice |
| |
| Long Term Storage: | -80°C |
| |
| Technical Info/Product Notes: |  |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
Novel inhibitors of microtubule organization and phragmoplast formation in diverse plant species: Y. Kimata, et al.; Life Sci. Alliance
6, e202201657 (2023),
Abstract;
BML-257, a small molecule that protects against drug induced liver injury in zebrafish: U. Jagtap, et al.; Chem. Res. Toxicol.
35, 1393 (2022),
Abstract;
Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling: E.Y. Lee, et al.; Nat. Commun.
13, 6455 (2022),
Abstract;
Full Text
High Resolution Crystal Structure and Chemical Screening Reveal Pantothenate Kinase as a New Target for Antifungal Development: S. Gihaz, et al.; Structures
30, 1494 (2022),
Abstract;
Large-scale identification of multiple classes of host defense peptide-inducing compounds for antimicrobial therapy: W. Lyu, et al.; Int. J. Mol. Sci.
23, 8400 (2022),
Abstract;
Full Text
Nephrotoxicity of calcineurin inhibitors in kidney epithelial cells is independent of calcineurin and NFAT signaling: A. Karolin, et al.; Front. Pharmacol.
12, 789080 (2022),
Abstract;
Full Text
Phosphorylation of RNA polymerase II by CDKC; 2 maintains the Arabidopsis circadian clock period: T.N. Uehara, et al.; Plant Cell Physiol.
63, 450 (2022),
Abstract;
Full Text
A cancer‐associated CDKN1B mutation induces p27 phosphorylation on a novel residue: a new mechanism for tumor suppressor loss‐of‐function: D. Bencivenga, et al.; Mol. Oncol.
15, 915 (2021),
Abstract;
Full Text
Anti-senescent drug screening by deep learning-based morphology senescence scoring: D. Kusumoto, et al.; Nat. Commun.
12, 257 (2021),
Abstract;
Full Text
FRET-based screening identifies p38 MAPK and PKC inhibition as targets for prevention of seeded α-synuclein aggregation: A. Svanbergsson, et al.; Neurotherapeutics
18, 1692 (2021),
Abstract;
Full Text
Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity: R. Seki, et al.; PLoS One
15, e0237030 (2020),
Abstract;
Full Text
JNK suppresses melanogenesis by interfering with CREB-regulated transcription coactivator 3-dependent MITF expression: J.H. Kim, et al.; Theranostics
10, 4017 (2020),
Abstract;
Full Text
BML-265 and tyrphostin AG1478 disperse the Golgi apparatus and abolish protein transport in human cells: G. Boncompain, et al.; Front. Cell. Dev. Biol.
7, 232 (2019),
Abstract;
Full Text
IL-4 together with IL-1β induces antitumor Th9 cell differentiation in the absence of TGF-β signaling: G. Xue, et al.; Nat. Commun.
10, 1376 (2019),
Abstract;
Full Text
Kinase inhibitors tyrphostin 9 and rottlerin block early steps of rabies virus cycle: Z. Lama, et al.; Antiviral Res.
168, 51 (2019),
Abstract;
Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds: D.J.M. Bergen, et al.; Front. Endocrinol. (Lausanne)
10, 6 (2019),
Abstract;
Full Text
Identification of antipsychotic drug fluspirilene as a potential anti-glioma stem cell drug: Y. Dong, et al.; Oncotarget
8, 111728 (2017),
Abstract;
Full Text
Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma: U.I. Scholl, et al.; J. Clin. Invest.
127, 2739 (2017),
Abstract;
Full Text
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury: S. Martens, et al.; Cell Death Dis.
8, e2904 (2017),
Abstract;
Full Text
Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells: J.H. Rhim, et al.; Sci. Rep.
6, 26547 (2016),
Abstract;
Full Text
Estradiol modulates myosin regulatory light chain phosphorylation and contractility in skeletal muscle of female mice: S. Lai, et al.; Am. J. Physiol. Endocrinol. Metab.
310, E724 (2016),
Abstract;
Human pluripotent stem cell-derived cortical neurons for high throughput medication screening in autism: A proof of concept study in SHANK3 haploinsufficiency syndrome: H. Darville, et al.; EBioMedicine
9, 293 (2016),
Application(s): Screening of compounds in humans with autism,
Abstract;
Therapeutic strategy for targeting aggressive malignant gliomas by disrupting their energy balance: A.M. Hegazy, et al.; J. Biol. Chem.
291, 21496 (2016),
Abstract;
Full Text
Identification of anti-proliferative kinase inhibitors as potential therapeutic agents to treat canine osteosarcoma: U. Mauchle, et al.; Vet. J.
205, 281 (2015),
Abstract;
MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish: P.R. Lundegaard, et al.; Chem. Biol.
15, 330 (2015),
Application(s): Screening of compounds in Zebrafish,
Abstract;
An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines: M. Burnette, et al.; Mol. Biosyst.
10, 2713 (2014),
Abstract;
Full Text
High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines: A. Ketley, et al.; Hum. Mol. Genet.
23, 1551 (2014),
Application(s): Screening of fibroblasts,
Abstract;
Full Text
Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel: H. Sun, et al.; Sci. Rep.
4, 4934 (2014),
Abstract;
Full Text
The mammalian circadian clock protein period counteracts cryptochrome in phosphorylation dynamics of circadian locomotor output cycles kaput (CLOCK): R. Matsumura, et al.; J. Biol. Chem.
289, 32064 (2014),
Abstract;
Full Text
A fluorescence-based thermal shift assay identifies inhibitors of mitogen activated protein kinase kinase 4: S.N. Krishna, et al.; PLoS One
8, e81504 (2013),
Abstract;
Full Text
Novel MicroRNA Reporter Uncovers Repression of Let-7 by GSK-3β: R. Guo, et al.; PLoS One
8, e66330 (2013),
Abstract;
Full Text
IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling: M.J. Schmeisser, et al.; J. Neurosci.
32, 5688 (2012),
Abstract;
Full Text
Protein kinase inhibitors that inhibit induction of lytic program and replication of Epstein-Barr virus: R. Goswami, et al.; Antiviral Res.
96, 296 (2012),
Abstract;
Small molecule screening identifies targetable zebrafish pigmentation pathways: S. Colanesi, et al.; Pigment Cell Melanoma Res.
25, 131 (2012),
Abstract;
Small-molecule modulators of Listeria monocytogenes biofilm development: U.T. Nguyen, et al.; Appl. Environ. Microbiol.
78, 1454 (2012),
Abstract;
Full Text
A small molecule discrimination map of the antibiotic resistance kinome: T. Shakya, et al.; Chem. Biol.
18, 1591 (2011),
Abstract;
Tumor suppression by RNA from C/EBPβ 3′ UTR through the inhibition of protein kinase Cε activity: Y. Wang, et al.; PLoS One
6, e16543 (2011),
Abstract;
Full Text
Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons: Y. Gao et al.; J. Neurochem.
113, 1331 (2010),
Abstract;
Cell treatment and lysis in 96-well filter-bottom plates for screening Bcr-Abl activity and inhibition in whole-cell extracts: M.R. Mand et al.; J. Biomol. Screen.
15, 434 (2010),
Abstract;
High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation: K.J. Leuchowius et al.; Mol. Cell. Proteomics
9, 178 (2010),
Abstract;
A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation: J. P. Saxe; Chem. Biol.
14, 1019 (2007),
Abstract;
High-content classification of nucleocytoplasmic import or export inhibitors: Y.-J. Kwon et al.; J. Biomol. Screen.
12, 621 (2007),
Abstract;
A robust screen for inhibitors and enhancers of phosphoinositide-3 kinase (PI3K) activities by ratiometric fluorescence superquenching: C. Stankewicz et al.; J. Biomol. Screen .
11, 413 (2006),
Abstract;
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition: J. Trapp et al.; J. Med. Chem.
49, 7307 (2006),
Abstract;
Biotinylated peptides for rapid identification of substrates and inhibitors of kinases and phosphatases with fluorescence superquenching
: S. Wittenburg, et al.; Assay Drug Dev. Technol.
4, 535 (2006),
Abstract;
Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling: P. O. Krutzik; Nat. Methods.
3, 361 (2006),
Abstract;
State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling: M. Sevecka et al.; Nat. Methods.
3, 825 (2006),
Abstract;
Related Products
