| ALX-804-891-C100 | 100 µg | 441.00 USD |  |
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| Alternative Name: | Interferon-inducible protein AIM2, Absent in melanoma 2 |
| Clone: | 3B10 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human AIM2 (aa 1-186) with GST-tag. |
| UniProt ID: | O14862 |
| Gene/Protein Identifier: | 9447 (Entrez GeneID) |
| Species reactivity: | Human |
| Applications: | IF, IP, WB |
| Recommended Dilutions/Conditions: | Western blot (0.5-2 μg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~39kDa by Western blot. |
| Purity Detail: | Affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide. |
| Shipping: | Blue Ice Not Frozen |
| Short Term Storage: | +4°C |
| Scientific Background: | AIM2 is a strong candidate as a tumor suppressor as it is a member of the HIN-200 (hemopoietic interferon-inducible, nuclear proteins containing a 200 amino acid repeat) family of proteins that have been shown to regulate cell growth and survival. The HIN-200 family of proteins consists of four members in human, IFI 16, MNDA, AIM2 and IFIXl. It has been reported that AIM2 is a receptor for cytosolic dsDNA, which forms an inflammasome complex with ASC to activate caspase-1-mediated processing of IL-1β. |
| Regulatory Status: | RUO - Research Use Only |
