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Presenilin 1 monoclonal antibody (APS 18)



ALX-804-555-C200	200 µg	544.00 USD
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Product Details

Clone:	APS 18

Host:	Mouse

Isotype:	IgG1

Immunogen:	Synthetic peptide corresponding to aa 313-334 (S³¹³KYNAESTER ESQDTVAENDDG³³⁴) of C-terminal human presenilin 1.

UniProt ID:	P49768

Species reactivity:	Human, Mouse, Rat Monkey

Crossreactivity:	Does not cross-react with presenilin 2.

Applications:	ELISA, ICC, WB

Recommended Dilutions/Conditions:	ELISA (1µg/ml) Immunocytochemistry (6µg/ml) Western Blot (12µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Application Notes:	Detects a band of ~18kDa (C-terminal fragment) and ~46kDa (full-length) presenilin 1 by Western blot.

Purity Detail:	Protein G affinity purified.

Formulation:	Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.

Handling:	Avoid freeze/thaw cycles.

Shipping:	Blue Ice

Long Term Storage:	-20°C

Regulatory Status:	RUO - Research Use Only

Presenilin 1 monoclonal antibody (APS 18) Immunocytochemistry

Figure: Immunocytochemistry using MAb to Presenilin 1 (APS 18) (Prod. No. ALX-804-555) shows endogenous presenilin 1 staining in Golgi and cellular vesicles in 4% paraformaldehyde fixed N2a cells."

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Product Literature References

Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies: A. Diehlmann, et al.; J. Neurosci. Res. 56, 405 (1999), Abstract;

Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071: B. Stahl, et al.; J. Biol. Chem. 274, 9141 (1999), Abstract;

Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation: G. Tesco, et al.; J. Biol. Chem. 273, 33909 (1998), Abstract;