Product Details
| Clone: | SYK-01 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Recombinant fragment (aa 5-360) of human Syk. |
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| UniProt ID: | P43405 |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | ICC, IHC (PS), IP, WB
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| Recommended Dilutions/Conditions: | Immunohistochemistry (paraffin sections, 5µg/ml)
Western Blot (1-2µg/ml, 60min.)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Purity Detail: | Protein A-affinity purified. |
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| Formulation: | Liquid. In PBS, pH 7.4, containing 15mM sodium azide. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A novel lipid raft-associated glycoprotein, TEC-21, activates rat basophilic leukemia cells independently of the type 1 Fc epsilon receptor: I. Halova, et al.; Int. Immunol.
14, 213 (2002),
Abstract;
Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation: V. Parravicini, et al.; Nat. Immunol.
3, 741 (2002),
Abstract;
Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation: M. Kovarova, et al.; Mol. Cell. Biol.
21, 8318 (2001),
Abstract;
Full Text
Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells: T.S. Manetz, et al.; Mol. Cell. Biol.
21, 3763 (2001),
Abstract;
Full Text
The Src homology 2 domain of Vav is required for its compartmentation to the plasma membrane and activation of c-Jun NH(2)-terminal kinase 1: R. Arudchandran, et al.; J. Exp. Med.
191, 47 (2000),
Abstract;
Full Text
Requirement for a negative charge at threonine 60 of the FcRgamma for complete activation of Syk: P.G. Swann, et al.; J. Biol. Chem.
274, 23068 (1999),
Abstract;
Full Text
Direct interaction of Syk and Lyn protein tyrosine kinases in rat basophilic leukemia cells activated via type I Fc epsilon receptors: M. Amoui, et al.; Eur. J. Immunol.
27, 321 (1997),
Abstract;
Protein tyrosine kinase Syk is involved in Thy-1 signaling in rat basophilic leukemia cells: P. Tolar, et al.; Eur. J. Immunol.
27, 3389 (1997),
Abstract;
