Product Details
| Alternative Name: | Phosphatase and tensin homolog deleted on chromosome 10 |
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| Clone: | 6H2.1 |
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| Host: | Mouse |
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| Isotype: | IgG |
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| Immunogen: | Recombinant human PTEN. |
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| UniProt ID: | P60484 |
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| Species reactivity: | Human, Mouse, Rat
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| Specificity: | Recognizes an epitope between aa 304-403. |
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| Applications: | ELISA, ICC, IHC, IP, WB
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| Recommended Dilutions/Conditions: | Immunoprecipitation (5µg)
Western Blot (1-5µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~60kDa by Western blot. |
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| Purity Detail: | Protein A-affinity purified. Sterile filtered. |
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| Formulation: | Liquid. In PBS. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Left) PTEN non-expressing neoplastic endometrial glands in a background of normal expressing glands and stroma. Right) Single band specificity of MAb to PTEN 6H2.1 on PTEN expressing cancer cell lines.
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Product Literature References
Molecular identification of latent precancers in histologically normal endometrium: G.L. Mutter, et al.; Cancer Res.
61, 4311 (2001),
Abstract;
Full Text
Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers: G.L. Mutter, et al.; J. Natl. Cancer Inst.
92, 924 (2000),
Abstract;
Changes in endometrial PTEN expression throughout the human menstrual cycle: G.L. Mutter, et al.; J. Clin. Endocrinol. Metab.
85, 2334 (2000),
Abstract;
Full Text
Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast: A. Perren, et al.; Am. J. Pathol.
155, 1253 (1999),
Abstract;
Full Text
PTEN suppresses breast cancer cell growth by phosphatase activity- dependent G1 arrest followed by cell death: L.P. Weng, et al.; Cancer Res.
59, 5808 (1999),
Abstract;
Full Text
