Product Details
| Alternative Name: | P2X purinoceptor 7, P2RX7 |
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| Clone: | HANO43 |
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| Host: | Rat |
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| Isotype: | IgG2b |
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| Immunogen: | Vector containing the cDNA of mouse purinergic receptor P2X7. |
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| UniProt ID: | Q9Z1M0 |
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| Species reactivity: | Mouse
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| Applications: | Flow Cytometry, ICC, IP
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| Recommended Dilutions/Conditions: | Flow Cytometry (1:1-1:10)
Immunocytochemistry (1:1-1:10)
Immunoprecipitation (1:1-1:10)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Positive Control: | HEK cells transfected with an expression plasmid for mouse purinergic receptor P2X7 can be used as positive control. |
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| Formulation: | Liquid. Hybridoma supernatant containing 0.02% sodium azide. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages: S. Bidula, et al.; Cell Death Dis.
10, 882 (2019),
Abstract;
Full Text
Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice: Y.G. Chen, et al.; J. Immunol.
186, 4278 (2011),
Abstract;
Murine epidermal Langerhans cells and keratinocytes express functional P2X7 receptors: J.N. Tran, et al.; Exp. Dermatol.
19, e151 (2010),
Abstract;
Full Text
ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site: S. Adriouch, et al.; FASEB J.
22, 861 (2007),
Abstract;
Full Text
Monitoring the expression of purinoceptors and nucleotide-metabolizing ecto-enzymes with antibodies directed against proteins in native conformation: S. Möller, et al.; Purinergic Signal.
3, 359 (2007),
Abstract;
Full Text
P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes: F. Aswad & G. Dennert; Cell. Immunol.
243, 58 (2006),
Abstract;
Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization: S. Adriouch, et al.; Cell. Immunol.
236, 72 (2005),
Abstract;
General Literature References
The P2X7 receptor: a key player in IL-1 processing and release: D. Ferrari, et al.; J. Immunol.
176, 3877 (2006), (Review),
Abstract;
Molecular properties of ATP-gated P2X receptor ion channels: C. Vial, et al.; Trends Pharmacol. Sci.
25, 487 (2004), (Review),
Abstract;
Molecular structure of P2X receptors: T.M. Egan, et al.; Curr. Top. Med. Chem.
4, 821 (2004), (Review),
Abstract;
Molecular physiology of P2X receptors: R.A. North; Physiol. Rev.
82, 1013 (2002), (Review),
Abstract;
