Fluorescent, membrane permeable probe of zinc ions which can be used to measure or visualize intracellular zinc. Used to demonstrate changes in zinc flux in cells undergoing early events of apoptosis.
Product Details
| Alternative Name: | (2-Methyl-8-(4-methylphenylsulfonylamino)quinolinyl)oxyacetic acid ethyl ester |
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| Formula: | C21H22N2O5S |
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| MW: | 414.5 |
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| CAS: | 181530-09-6 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in 100% ethanol, methanol or DMSO; slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Scientific Background: | Zinc (Zn) is the second most abundant transition metal in the body ant it is essential as catalytic, structural and regulatory ion. Zinc ions are involved in homeostasis, immune responses, oxidative stress, apoptosis and aging. Zinc has been proposed to function as a conventional neurotransmitter for the presynaptic neuron and as a transmembrane signal to traverse the postsynaptic neuron. Aberrant zinc metabolism is associated with many neurological diseases including Alzheimer’s disease, Parkinson’s disease and epilepsy. The most suitable technique for in vivo monitoring of zinc has been proven to be fluroescent imaging. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
Intracellular zinc during cell activation and zinc deficiency: B. Rolles, et al.; J. Trace Elem. Med. Biol.
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Abstract;
Inhibition of MMP-13 with modified polymer particles: H. Tran, et al.; Surf. Sci. 648, 371 (2016), Application(s): Cell culture,
Chemical-Biological Properties of Zinc Sensors TSQ and Zinquin: Formation of Sensor-Zn-Protein Adducts versus Zn(Sensor)2 Complexes: A.B. Nowakowski, et al.; Inorg. Chem.
54, 11637 (2015),
Application(s): Fluorescence Microscopy and Spectrofluorimetry in Cultured Cells,
Abstract;
Intracellular zinc movement and its effect on the carbohydrate metabolism of isolated rat hepatocytes: I.A. Brand & J. Kleineke; J. Biol. Chem.
271, 1941 (1996),
Abstract;
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Flux of intracellular labile zinc during apoptosis (gene-directed cell death) revealed by a specific chemical probe, Zinquin: P.D. Zalewski, et al.; Chem. Biol.
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Abstract;
Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zinc: P. Coyle, et al.; Biochem. J.
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Abstract;
Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc: P.D. Zalewski, et al.; J. Histochem. Cytochem.
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Abstract;
Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II): P.D. Zalewski, et al.; Biochem. J.
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Abstract;
General Literature References
Mechanism and regulation of cellular zinc transport: I. Sekler, et al.; Mol. Med.
13, 337 (2007),
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Sticky fingers: zinc-fingers as protein-recognition motifs: R. Gamsjaeger, et al.; TIBS
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Abstract;
Zinc: a multipurpose trace element: M. Stefanidou, et al.; Arch. Toxicol.
80, 1 (2006),
Abstract;
Fluorescent detection of zinc in biological systems: recent development on the design of chemosensors and biosensors: P. Jiang & Z. Guo; Coord. Chem. Rev. 248, 205 (2004),
Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death: A.Q. Truong-Tran, et al.; J. Nutr.
130, 1459S (2000),
Abstract;
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