Cell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No. BML-EI126) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes in vivo.
Product Details
| Alternative Name: | CpdA, 2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride |
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| Formula: | C11H14ClNO2 . HCl |
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| MW: | 227.7 . 36.5 |
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| CAS: | 14593-25-0 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO, 100% ethanol or water. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stock solutions in ethanol are stable for up to 1 month when stored at -80°C. |
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| Handling: | Protect from moisture. After reconstitution, prepare aliquots and store at -80°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Relative contribution of molecular mechanisms to cumulative ligand-mediated downregulation of GRα: L.L. Spies, et al.; Biochem. Biophys. Res. Commun.
602, 113 (2022),
Abstract;
Glucocorticoids decrease the production of glucagon-like peptide-1 at the transcriptional level in intestinal l-cells: T. Sato, et al.; Mol. Cell Endocrinol.
406, 60 (2015),
Application(s): Cell Culture, Assay,
Abstract;
A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance: V. Gossye, et al.; Ann. Rheum. Dis.
69, 291 (2010),
Abstract;
Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis: G. van LOO, et al.; Mol. Endocrinol.
24, 310 (2010),
Abstract;
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis: P. Dewint, et al.; J. Immunol.
180, 2608 (2008),
Abstract;
A fully dissociated compound of plant origin for inflammatory gene repression: K. De Bosscher, et al.; PNAS
102, 15827 (2005),
Abstract;
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