Selective agonist for group II mGluRs. Inhibits the NADPH-oxidase dependent ROS system.
Product Details
| Alternative Name: | LY-314,593, (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid |
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| Formula: | C6H10N2O4 |
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| MW: | 174.2 |
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| CAS: | 169209-63-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white powder. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Modulation of sensory inhibition in the ventrobasal thalamus via activation of group II metabotropic glutamate receptors by 2R,4R-aminopyrrolidine-2,4-dicarboxylate: T.E. Salt & J.P. Turner; Exp. Brain Res.
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Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists: R. Mistry, et al.; Br. J. Pharmacol.
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Specific group II metabotropic glutamate receptor activation inhibits the development of kindled epilepsy in rats: P.J. Atwell, et al.; Brain Res.
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Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase: J.A. Monn, et al.; J. Med. Chem.
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