Racemic modification of (-)-Huperzine A (Prod. No. ALX-550-065) with acetylcholinesterase inhibitor activity. Has a weaker biological activity than (-)Huperzine A. Neurotoxic.
Product Details
| Alternative Name: | (±)-Selagine |
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| Formula: | C15H18N2O |
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| MW: | 242.3 |
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| Source: | Synthetic. |
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| CAS: | 120786-18-7 |
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| MI: | 14: 4755 |
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| Purity: | ≥95% |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in dilute aqueous acids or chloroform. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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2016, 9729818 (2016),
Abstract;
Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine: R. Wang, et al.; Acta Pharmacol. Sin.
27, 1 (2006),
Abstract;
Huperzine A, a potential therapeutic agent for treatment of Alzheimer’s disease: D.L. Bai, et al.; Curr. Med. Chem.
7, 355 (2000), (Review),
Abstract;
Huperzine A ameliorates the spatial working memory impairments induced by AF64A: Q.X. Zhi, et al.; NeuroReport
6, 2221 (1995),
Abstract;
An Improved Synthetic Route to Huperzine A; New Analogues and Their Inhibition of Acetylcholinesterase: A.P. Kozikowski, et al.; J. C. S. Chem. Commun. 860 (1993),
Mechanism of inhibition of cholinesterases by huperzine A: Y. Ashani, et al.; BBRC
184, 719 (1992),
Abstract;
Potencies and stereoselectivities of enantiomers of huperzine A for inhibition of rat cortical acetylcholinesterase: M. McKinney, et al.; Eur. J. Pharmacol.
203, 303 (1991),
Abstract;
Synthesis and Biological Evaluation of (±)-Z-Huperzine A: A.P. Kozikowski, et al.; Tetrahedron Lett. 31, 6159 (1990),
A practical synthesis of the Chinese "nootropic" agent huperzine A: a possible lead in the treatment of Alzheimer's disease: Y. Xia & A.P. Kozikowski; JACS 111, 4116 (1989),
Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat: X.C. Tang, et al.; J. Neurosci. Res.
24, 276 (1989),
Abstract;
The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat: J.-S. Liu, et al.; Can. J. Chem. 64, 837 (1986),
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