Product Details
| Alternative Name: | IL-1RI, Interleukin-1 receptor type I, CD121a |
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| MW: | ~83kDa (SDS-PAGE). |
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| Source: | Produced in HEK 293 cells. Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused to the Fc portion of human IgG1. |
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| UniProt ID: | P14778 |
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| Concentration: | 1mg/ml after reconstitution. |
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| Formulation: | Lyophilized. Contains PBS. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Endotoxin Content: | <0.1EU/µg purified protein (LAL test; Lonza). |
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| Specificity: | Binds to human IL-1 (interleukin-1). |
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| Reconstitution: | Reconstitute with 50µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 6 months after receipt when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C. |
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| Technical Info/Product Notes: | Historical data has shown that IL-1 receptor blocks IL-1 activity. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Inhibition of IL-1 (Prod. No.
ALX-522-056) induced NF-kB activation by IL-1R:Fc. The degradation of IkBa upon IL-1 stimulation previously incubated with IL-1R:Fc was measured by Western blot. "
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General Literature References
IL-1 and IL-18 receptors, and their extended family: J.E. Sims, et al.; Curr. Opin. Immunol.
14, 117 (2002),
Abstract;
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense: L.A. O'Neill; Sci. STKE
2000, RE1 (2000),
Abstract;
Cytokine receptors and signal transduction: A. Miyajima, et al.; Annu. Rev. Immunol.
10, 295 (1992),
Abstract;
cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily: J.E. Sims, et al.; Science
241, 585 (1988),
Abstract;
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