Selective activator of cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
Product Details
| Alternative Name: | 8-pCPT-cGMP . Na |
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| Formula: | C16H14ClN5O7PS . Na |
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| MW: | 486.8 . 23.0 |
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| CAS: | 51239-26-0 |
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| Purity: | ≥99% (HPLC) |
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| Identity: | Determined by ESI-MS and UV/VIS. |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol.
43, 2591 (1992),
Abstract;
Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets: J. Geiger, et al.; PNAS
89, 1031 (1992),
Abstract;
