Oxidized form of the nucleoside guanosine. Formed in vivo by the free radical oxidation of RNA molecules, with subsequent degradation and cleavage of the nucleic acid.
Product Details
| Alternative Name: | 8-OHG |
| |
| Formula: | C10H13N5O6 |
| |
| MW: | 299.2 |
| |
| CAS: | 3868-31-3 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Identity: | Determined by UV-VIS and ESI-MS. |
| |
| Appearance: | White to off-white powder. |
| |
| Solubility: | Soluble in conc. NaOH. Once solubilized it can be further diluted and neutralized with water. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Guanosine and its modified derivatives are endogenous ligands for TLR7: T. Shibata, et al.; Int. Immunol.
28, 211 (2016),
Abstract;
Levels of 8-hydroxydeoxyguanosine as a marker of DNA damage in human leukocytes: M. Lodovici, et al.; Free Radic. Biol. Med.
28, 13 (2000),
Abstract;
Involvement of oxidative stress in motorcycle exhaust particle-induced DNA damage and inhibition of intercellular communication: M.L. Kuo, et al.; Mutat. Res.
413, 143 (1998),
Abstract;
Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool: J.Y. Mo, et al.; PNAS
89, 11021 (1992),
Abstract;
8-Substituted guanosine and 2'-deoxyguanosine derivatives as potential inducers of the differentiation of Friend erythroleukemia cells: T.S. Lin, et al.; J. Med. Chem.
28, 1194 (1985),
Abstract;
