Potent selective inhibitor of cGMP-dependent protein kinase 1α, 1β and type II. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS (Prod. No. ALX-480-072) or Rp-8-Br-cGMPS (Prod. No. BML-CN216).
Product Details
| Alternative Name: | Rp-8-pCPT-cGMPS . TEA, 8-pCPT-cGMPS . TEA, Rp-Isomer |
| |
| Formula: | C16H14ClN5O6PS2 . C6H16N |
| |
| MW: | 502.9 . 102.2 |
| |
| CAS: | 153660-04-9 |
| |
| Purity: | ≥99% (HPLC) |
| |
| Identity: | Determined by UV and ESI-MS. |
| |
| Appearance: | White to off-white crystalline powder. |
| |
| Solubility: | Soluble in water and aqueous buffers. |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes: S. Chen, et al.; Biochem. Biophys. Res. Commun.
461, 1 (2015),
Application(s): Cell Culture,
Abstract;
Antagonists of cyclic nucleotide-gated channels and molecular mapping of their site of action: R.H. Kramer & G.R. Tibbs; J. Neurosci.
16, 1285 (1996),
Abstract;
The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms: D.M. Gamm, et al.; J. Biol. Chem.
270, 27380 (1995),
Abstract;
Full Text
(Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor: E. Butt, et al.; Eur. J. Pharmacol.
269, 265 (1994),
Abstract;
Related Products
