Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS (Prod. No. BML-CN135, and Prod. No. ALX-480-085). Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP (Prod. No. BML-CN115).
Product Details
| Alternative Name: | Rp-8-Br-cAMPS . Na, 8-Br-cAMPS . Na, Rp-isomer |
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| Formula: | C10H10BrN5O5PS . Na |
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| MW: | 423.2 . 23.0 |
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| CAS: | 129735-00-8 |
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| Purity: | ≥99% (HPLC) |
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| Identity: | Identity determined by MS and UV. |
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| Appearance: | White to off-white powder. |
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| Solubility: | 250 mM soluble in water, aqueous solutions, DMSO or dimethyl formamide. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Solutions should be stored in the refrigerator and should be lyophilized and frozen for longer storage periods. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway: G. Mottola, et al.; PLoS One
12, e0174936 (2017),
Abstract;
Full Text
Novel (Rp)-cAMPS analogs as tool for inhibition of cAMP-kinase in cell culture: B.T. Gjertsen, et al.; J. Biol. Chem.
270, 20599 (1995),
Abstract;
Full Text
Activation of intestinal CFTR Cl- channel by heat-stable enterotoxin and guanylin via cAMP-dependent protein kinase: A.C. Chao, et al.; EMBO J.
13, 1065 (1994),
Abstract;
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