Replaces Prod. #: BML-CA201
Potent and highly selective calcium ionophore. Ca2+/ionomycin complex forms between pH 7-9.5 which has intense UV absorption. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase. Useful tool for increasing intracellular Ca2+ concentration. More effective than A23187. Non fluorescent. Has been used at 4nM and 2-4µM (whole cells).
Product Details
| Formula: | C41H72O9 |
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| MW: | 709.0 |
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| Source: | Isolated from Streptomyces conglobatus. |
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| CAS: | 56092-81-0 |
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| Purity: | ≥90% (HPLC, TLC) |
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| Appearance: | Waxy yellow to colorless material |
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| Solubility: | Soluble in DMSO or methanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Stock solutions are stable for 1 year when stored at +4°C. |
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| Handling: | Protect from light. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Mesenchymal stem cells induced CD4+ T cell apoptosis in treatment of lupus mice: S. Huang, et al.; Biochem. Biophys. Res. Commun.
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Chrysin suppresses human CD14+ monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis: K. Zhang, et al.; J. Neuroimmunol.
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Application(s): Intracellular cytokine staining,
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Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis: K. Rui, et al.; Cell. Mol. Immunol.
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Application(s): Flow cytometric analysis in mouse cells,
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Puerarin attenuates smoke inhalation injury by regulation of Th1/Th2 expression and inhibition of Th17 cells in rats: F. Zhang, et al.; Int. Immunopharmacol.
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The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations: T. Tian, et al.; PLoS One
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Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line: C.H. Park, et al.; Carcinogenesis
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ctivation of stress response by ionomycin in rat hepatoma cells: A. S. Sreedhar & U. K. Srinivas; J. Cell. Biochem.
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Abstract;
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation: K. Brown, et al.; Science
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Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis: K.M. Aagaard-Tillery & D.F. Jelinek; J. Immunol.
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Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons: N. Takei & Y. Endo; Brain Res.
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Contrasting effect of transforming growth factor type beta 1 (TGF-beta 1) on proliferation and interleukin-2 receptor expression in activated and rapidly cycling immature (CD3-CD4-CD8-) thymocytes: A. Dupuy d'Angeac, et al.; J. Cell. Physiol.
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Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose: H.C. Lee; J. Biol. Chem.
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Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol: G. Kuznetsov, et al.; J. Biol. Chem.
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Structure of ionomycin - a novel diacidic polyether antibiotic having high affinity for calcium ions: B.K. Toeplitz at al.; JACS 101, 3344 (1979),
Characterization of ionomycin as a calcium ionophore: C.M. Liu & T.E. Herman; J. Biol. Chem.
253, 5892 (1978),
Abstract;
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