Replaces Prod. #: BML-CC103
Folic acid antagonist. Potent inhibitor of dihydrofolate reductase. Induces apoptosis. Inhibits DNA synthesis. Anticancer agent.
Product Details
| Alternative Name: | (+)-Amethopterin, 4-Amino-10-methylfolic acid, Methylaminopterin, MTX |
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| Formula: | C20H22N8O5 . H2O |
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| MW: | 454.5 |
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| CAS: | 133073-73-1 |
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| MI: | 14: 5985 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Yellow powder. |
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| Solubility: | Soluble in alkaline solution; insoluble in water, 100% ethanol or ether. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Antiproliferative and antiinflammatory effects of methotrexate on cultured differentiating myeloid monocytic cells (THP-1) but not on synovial macrophages from patients with rheumatoid arthritis: M. Cutolo, et al.; J. Rheumatol.
27, 2551 (2000),
Abstract;
Mechanisms of action of methotrexate: L. Genestier, et al.; Immunopharmacology
47, 247 (2000),
Abstract;
Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?: L.D. Fairbanks, et al.; Biochem. J.
342, 143 (1999),
Abstract;
Activation-dependent lymphocyte apoptosis induced by methotrexate: R. Paillot, et al.; Transplant. Proc.
30, 2348 (1998),
Abstract;
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells: L. Genestier, et al.; J. Clin. Invest.
102, 322 (1998),
Abstract;
Methotrexate induces apoptotic cell death in human keratinocytes: M. Heenen, et al.; Arch. Dermatol. Res.
290, 240 (1998),
Abstract;
Characteristics of cancer cell death after exposure to cytotoxic drugs in vitro: L.I. Huschtscha, et al.; Br. J. Cancer.
73, 54 (1996),
Abstract;
Cell-cycle-stage specificity of the methotrexate block as resolved by X-ray-induced chromosome damage: V.B. Richardson, et al.; Cytogenet. Cell. Genet.
66, 126 (1994),
Abstract;
Polymerization of tubulin in apoptotic cells is not cell cycle dependent: S.M. Pittman, et al.; Exp. Cell. Res.
215, 263 (1994),
Abstract;
