Cell permeable probe for the detection of intracellular oxidative stress. ACP can easily be deprotected with esterases to cyclic hydroxylamines, which are oxidized by ROS leading to ESR-detectable nitroxide radicals.
Product Details
| Alternative Name: | 1-Acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine |
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| Formula: | C11H20N2O3 |
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| MW: | 228.3 |
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| Purity: | ≤0.05% paramagnetic impurities (by EPR) |
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| Appearance: | White to off-white crystalline powder. |
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| Solubility: | Soluble in water, methanol, 100% ethanol or DMSO. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Pharmacokinetic study of acyl-protected hydroxylamine probe, 1-acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine, for in vivo measurements of reactive oxygen species: K. Saito, et al.; Free Radic. Biol. Med.
36, 517 (2004),
Abstract;
Measurement of oxidative stress by EPR radical-probe technique: L. Valgimigli, et al.; Free Radical Biol. Med.
31, 708 (2001), (Review),
Abstract;
In vivo EPR imaging by using an acyl-protected hydroxylamine to analyze intracerebral oxidative stress in rats after epileptic seizures: H. Yokoyama, et al.; Magn. Reson. Imaging
18, 875 (2000),
Abstract;
Sensitive ESR determination of intracellular oxidative stress by using acyl-protected hydroxylamines as new spin reagents: O. Itoh, et al.; Chem. Lett.
29, 304 (2000),
Abstract;
