Cell permeable spin trap for both in vivo and in vitro studies.
Product Details
| Alternative Name: | N-tert-Butyl-α-phenylnitrone |
| |
| Formula: | C11H15NO |
| |
| MW: | 177.3 |
| |
| CAS: | 3376-24-7 |
| |
| MI: | 14: 7056 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Appearance: | White to off-white crystalline solid. |
| |
| Solubility: | Soluble in DMSO or 100% ethanol; slightly soluble in water. |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Handling: | Protect from light. |
| |
| Technical Info/Product Notes: | For selected literature references on spin trapping and beer please click here. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Free radical formation by Lactobacillus acidophilus NCFM is enhanced by antioxidants and decreased by catalase: A.B. Hougaard, et al. ; Food Res. Int. 79, 81 (2016), Application(s): Cell culture,
In vivo detection of free radicals induced by diethylnitrosamine in rat liver tissue: K. Yamada, et al.; Free Radic. Biol. Med.
40, 2040 (2006),
Abstract;
Protective effect of spin trap agent, N-tert-butyl-alpha-phenylnitrone on hyperoxia-induced oxidative stress and its potential as a nitric oxide donor: K. Saito & H. Yoshioka; Free Radic. Res.
36, 143 (2002),
Abstract;
The nitrone spin trap PBN alters the cellular response to H(2)O(2): activation of the EGF receptor/ERK pathway: W.N. Hassan, et al.; Free Radic. Biol. Med.
32, 551 (2002),
Abstract;
The spin trapping agent PBN stimulates H2O2 -induced Erk and Src kinase activity in human neuroblastoma cells: P. Kelicen, et al.; Neuroreport
13, 1057 (2002),
Abstract;
Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059: K.R. Maples, et al.; Free Radic. Res.
34, 417 (2001),
Abstract;
Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activa: P.A. Lapchak, et al.; Stroke
32, 147 (2001),
Abstract;
Full Text
Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFkappaB activation offering protection against chemically induced diabetes: E. Ho, et al.; Free Radic. Biol. Med.
28, 604 (2000),
Abstract;
Pharmacologic properties of phenyl N-tert-butylnitrone: Y. Kotake; Antioxid. Redox Signal.
1, 481 (1999), Review,
Abstract;
PBN spin trapping of free radicals in the reperfusion-injured heart. Limitations for pharmacological investigations: N. Vrbjar, et al.; Mol. Cell. Biochem.
186, 107 (1998),
Abstract;
Release of nitric oxide from a spin trap, N-tert-butyl-alpha-phenylnitrone, under various oxidative conditions: K. Saito, et al.; Biol. Pharm. Bull.
21, 401 (1998),
Abstract;
Evidence for a novel pentyl radical adduct of the cyclic nitrone spin trap MDL 101,002: J.L. Dage, et al.; Free Radic. Biol. Med.
22, 807 (1997),
Abstract;
Necrosis of the substantia nigra, pars reticulate, in flurothyl-induced status epilepticus is ameliorated by the spin trap alpha phenyl-N-tert-butyl nitrone: Q.P. He, et al.; Free Radic. Biol. Med.
22, 917 (1997),
Abstract;
Optimal time and dosage of phenyl N-tert-butyl nitrone (PBN) for the inhibition of nitric oxide synthase induction in mice: T. Miyajima & Y. Kotake; Free Radic. Biol. Med.
22, 463 (1997),
Abstract;
Protective action of nitrone-based free radical traps against oxidative damage to the central nervous system: R.A. Floyd; Adv. Pharmacol.
38, 361 (1997),
Abstract;
The structure of free radical metabolites detected by EPR spin trapping and mass spectroscopy from halocarbons in rat liver microsomes: H. Sang, et al.; Free Radic. Biol. Med.
22, 843 (1997),
Abstract;
N-tert-butyl-alpha-phenylnitrone: a free radical trap with unanticipated effects on diaphragm function: K.A. Andersen, et al.; J. Appl. Physiol.
80, 862 (1996),
Abstract;
Iron supplementation generates hydroxyl radical in vivo. An ESR spin- trapping investigation: M.B. Kadiiska, et al.; J. Clin. Invest.
96, 1653 (1995),
Abstract;
The spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone stimulates peroxidase-mediated oxidation of deferoxamine. Implications for pharmacological use of spin-trapping agents: M.L. McCormick, et al.; J. Biol. Chem.
270, 29265 (1995),
Abstract;
