Replaces Prod. #: BML-FR107
Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Inhibits neuronal apoptosis.
Product Details
Formula: | C48H28MnN4O8Cl |
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MW: | 879.2 |
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Purity: | ≥95% (TLC) |
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Appearance: | Black crystalline powder. |
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Solubility: | Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed. |
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Shipping: | Ambient Temperature |
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Short Term Storage: | +4°C |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 2 years after receipt when stored at -20°C. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Ao Overproduction of nitric oxide by endothelial cells and macrophages contributes to mitochondrial oxidative stress in adrenocortical cells and adrenal insufficiency during endotoxemia: C.N. Wang, et al.; Free Radic. Biol. Med.
83, 31 (2015),
Application(s): Injection,
Abstract;
Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis: H. Dussmann, et al.; J. Biol. Chem.
278, 12645 (2003),
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Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen.: S. Kotamraju, et al.; J. Biol. Chem.
275, 33585 (2000),
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Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem.
275, 13613 (2000),
Abstract;
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Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation: P. Ghafourifar, et al.; J. Biol. Chem.
274, 31185 (1999),
Abstract;
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Reactive oxygen species regulate activation-induced T cell apoptosis:: D.A. Hildeman, et al.; Immunity
10, 735 (1999),
Abstract;
Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabó, et al.; FEBS Lett.
381, 82 (1996),
Abstract;
A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther.
275, 1227 (1995),
Abstract;
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem.
269, 23471 (1994),
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General Literature References
Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic: M. Patel; J. Neurochem.
71, 1068 (1998),
Abstract;
The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock: B. Zingarelli, et al.; Br. J. Pharmacol.
120, 259 (1997),
Abstract;