Replaces Prod. #: BML-CT106
Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.
Product Details
| Alternative Name: | 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, R-837 |
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| Formula: | C14H16N4 |
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| MW: | 240.3 |
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| CAS: | 99011-02-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | After reconstitution, prepare aliquots and store at -20°C. |
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| Technical Info/Product Notes: | Stimulation of TLR7 can be achieved with 1-10µg/ml of the compound for 6 to 24 hours. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The Local Activation of Toll-like Receptor 7 (TLR7) Modulates Colonic Epithelial Barrier Function in Rats: J. Estevez & V. Martinez; Int. J. Mol. Sci.
24, 1254 (2023),
Abstract;
TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons: L. Maatouk, et al.; Nat. Commun.
9, 2450 (2018),
Abstract;
Full Text
Poly (I: C) and imiquimod induced immune responses and their effects on the survival of olive flounder (Paralichthys olivaceus) from viral haemorrhagic septicaemia: S. Avunje, et al.; Fish Shellfish Immunol.
17, 338 (2017),
Abstract;
Tamoxifen downregulates MxA expression by suppressing TLR7 expression in PBMCs of males infected with HCV: I.O. Fawzy, et al.; J. Med. Virol.
86, 1113 (2014),
Abstract;
Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation: T. Hirai, et al.; J. Immunol.
190, 4805 (2013),
Abstract;
Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in peripheral blood mononuclear cells of patients infected with hepatitis C virus: S.S. Tayel, et al.; Arch. Virol.
158, 1755 (2013),
Abstract;
Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands: C. Sekine, et al.; Int. Immunol.
21, 295 (2009),
Abstract;
Imiquimod as an antiangiogenic agent: V.W. Li, et al.; J. Drugs Dermatol.
4, 708 (2005),
Abstract;
Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis: S. Majewski, et al.; Int. J. Dermatol.
44, 14 (2005),
Abstract;
In vivo and in situ modulation of the expression of genes involved in metastasis and angiogenesis in a patient treated with topical imiquimod for melanoma skin metastases: C. Hesling, et al.; Br. J. Dermatol.
150, 761 (2004),
Abstract;
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway: H. Hemmi, et al.; Nat. Immunol.
3, 196 (2002),
Abstract;
Imiquimod applied topically: a novel immune response modifier and new class of drug: R.L. Miller, et al.; Int. J. Immunopharmacol.
21, 1 (1999),
Abstract;
General Literature References
Imiquimod is a strong inhibitor of tumor cell-induced angiogenesis: S. Majewski, et al.; Int. J. Dermatol.
44, 14 (2005),
Abstract;
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