Cell permeable and orally available flavonoid. Induces apoptosis in tumor cells but not in healthy cells by increasing peroxide production. Displays anti-inflammatory properties. Suppresses the release of nitric oxide (NO) by inducible nitric oxide synthase (iNOS; NOS II), PGE2 by cyclooxygenase-2 (COX-2), proinflammatory cytokines, MCP-1 gene expression and NF-κB activation. Antioxidant.
Product Details
| Alternative Name: | 5,7-Dihydroxy-8-methoxyflavone |
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| Formula: | C16H12O5 |
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| MW: | 284.3 |
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| CAS: | 632-85-9 |
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| RTECS: | LK8331000 |
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| Purity: | ≥98% (HPLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to yellow solid. |
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| Solubility: | Soluble in DMSO (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLC{gamma}1- and Ca2+-dependent apoptosis: S. Baumann, et al.; Blood
111, 2354 (2007),
Abstract;
Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action: R. Enomoto, et al.; J. Pharmacol. Sci.
104, 355 (2007),
Abstract;
Full Text
Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis: S.C. Fas, et al.; Blood
108, 3700 (2006),
Abstract;
Full Text
Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells: S.O. Lee, et al.; BBRC
351, 118 (2006),
Abstract;
Anti-inflammatory plant flavonoids and cellular action mechanisms: H.P. Kim, et al.; J. Pharmacol. Sci.
96, 229 (2004),
Abstract;
Full Text
Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1: Y.C. Chen, et al.; Arch. Toxicol.
76, 351 (2002),
Abstract;
Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells: Y.L. Chang, et al.; Mol. Pharmacol.
60, 507 (2001),
Abstract;
Full Text
Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells: Y.S. Chi, et al.; Biochem. Pharmacol.
61, 1195 (2001),
Abstract;
The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production: H. Kim, et al.; Neurosci. Lett.
309, 67 (2001),
Abstract;
Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin: D.E. Shieh, et al.; Anticancer Res.
20, 2861 (2000),
Abstract;
Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines: S. Ikemoto, et al.; Urology
55, 951 (2000),
Abstract;
Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages: I. Wakabayashi; Pharmacol. Toxicol.
84, 288 (1999),
Abstract;
The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin: C.C. Lin & D.E. Shieh; Am. J. Chin. Med.
24, 31 (1996),
Abstract;
