Antibacterial, antifungal, cytotoxic and antialgal activity. Has been shown to inhibit NADPH oxidase activation in macrophages. Induces apoptosis by phosphorylation of p38 MAP kinase. Additionally, inhibits the association of p47-phox and Rac (NADPH oxidase cytosolic components) to the plasma membrane in macrophages.
Product Details
Alternative Name: | Prodigiosine, 4-Methoxy-5-[(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-2,2’-bi[1H-pyrrole] |
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Formula: | C20H25N3O |
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MW: | 323.4 |
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Source: | Isolated from Serratia marcescens. |
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CAS: | 82-89-3 |
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MI: | 14: 7767 |
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Purity: | ≥95% (HPLC) |
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Appearance: | Yellow to dark red solid. |
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Solubility: | Soluble in dioxane, pyridine, methylene chloride, hexane, chloroform or methanol; insoluble in water. |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Handling: | Protect from light. |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A prodigiosin analogue inactivates NADPH oxidase in macrophage cells by inhibiting assembly of p47phox and Rac: T. Nakashima, et al. ; J. Biochem.
143, 107 (2008),
Abstract;
Mode of action of an antialgal agent produced by a marine gammaproteobacterium against Chattonella marina: T. Nakashima, et al. ; Aquat. Microb. Ecol.
45, 255 (2006),
Abstract;
Full Text
Producing mechanism of an algicidal compound against red tide phytoplankton in a marine bacterium gamma-proteobacterium: T. Nakashima, et al. ; Appl. Microbiol. Biotechnol.
73, 684 (2006),
Abstract;
Apoptosis-mediated cytotoxicity of prodigiosin-like red pigment produced by gamma-Proteobacterium and its multiple bioactivities: T. Nakashima, et al. ; Biol. Pharm. Bull.
28, 2289 (2005),
Abstract;
Characterization of bacterium isolated from the sediment at coastal area of Omura Bay in Japan and several biological activities of pigment produced by this isolate: T. Nakashima, et al. ; Microbiol. Immunol.
49, 407 (2005),
Abstract;
Evaluation of the anti-Trichophyton activity of a prodigiosin analogue produced by gamma-proteobacterium, using stratum corneum epidermis of the Yucatan micropig: T. Nakashima, et al.; J. Infect. Chemother.
11, 123 (2005),
Abstract;