Ionophore antibiotic. Potential anticancer compound.
Product Details
| Formula: | C36H63N3O9 |
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| MW: | 681.9 |
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| Source: | Isolated from Fusarium sp. |
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| CAS: | 2503-13-1 |
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| MI: | 14: 3585 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Identity determined by 1H-NMR, 13C-NMR and MS. |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in 100% ethanol, methanol, DMSO and dimethyl formamide; almost insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Scientific Background: | Enniatins are a family of depsipeptides produced by several species of the filamentous fungus Fusarium. Enniatins have initially been shown to act as ionophores. Later, their effects on acyl-CoA cholesterol transferase, ABC-transporters and the selectivity of their antitumor action came to the fore. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Fate of Fusarium Toxins during Brewing: K. Habler, et al.; J. Agric. Food Chem.
64, 190 (2017),
Abstract;
Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res.
54, 87 (2015),
Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis,
Full Text
Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation: W. Wätjen et al.; Mol. Nutr. Food Res.
53, 431 (2009),
Abstract;
Interactions between ABC-transport proteins and the secondary Fusarium metabolites enniatin and beauvericin: R. Dornetshuber et al.; Mol. Nutr. Food Res.
53, 904 (2009),
Abstract;
Oxidative stress and DNA interactions are not involved in Enniatin- and Beauvericin-mediated apoptosis induction: R. Dornetshuber et al.; Mol. Nutr. Food Res.
53, 1112 (2009),
Abstract;
Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells: R. Dornetshuber, et al.; Chem. Res. Toxicol.
20, 465 (2007),
Abstract;
Cytotoxicity of enniatins A, A1, B, B1, B2 and B3 from Fusarium avenaceum: L. Ivanova et al.; Toxicon
47, 868 (2006),
Abstract;
Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae: K. Hiraga, et al.; BBRC
328, 1119 (2005),
Abstract;
Interaction of cyclic peptides and depsipeptides with calmodulin: K.A. Mereish, et al.; Pept. Res.
3, 233 (1990),
Abstract;
"Sandwich" complexation in cyclopeptides and its implications in membrane processes: V.T. Ivanov; Ann. N. Y. Acad. Sci.
264, 221 (1975),
Abstract;
Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria: E. Gaumann, et al.; Experientia 3, 202 (1947),
