Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria and Chlamydia trachomatis.
Product Details
| Alternative Name: | 7-(3-Amino-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid . tosylate, A-64730 |
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| Formula: | C19H15F3N4O3 . C7H8O3S |
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| MW: | 404.4 . 172.2 |
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| CAS: | 115964-29-9 |
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| MI: | 14: 9555 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to yellow crystalline solid. |
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| Solubility: | Slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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34, 465 (2007),
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8, 19 (2002), (Review),
Abstract;
Antibacterial activities of tosufloxacin against anaerobic bacteria and the electron micrograph of its bactericidal effects: M. Takahata & T. Nishino; Chemotherapy
43, 153 (1997),
Abstract;
Stereoselective analysis of the disposition of tosufloxacin enantiomers in man: R. Minami, et al.; Eur. J. Clin. Pharmacol.
45, 489 (1993),
Abstract;
In-vitro activity of tosufloxacin, a new quinolone antibacterial agent: M.A. Cooper, et al.; J. Antimicrob. Chemother.
29, 639 (1992),
Abstract;
The in-vitro activity of tosufloxacin, a new fluorinated quinolone, compared with that of ciprofloxacin and temafloxacin: A. King, et al.; J. Antimicrob. Chemother.
28, 719 (1991),
Abstract;
In vitro activity of tosufloxacin, a new quinolone, against respiratory pathogens derived from cystic fibrosis sputum: A.G. Arguedas, et al.; Antimicrob. Agents Chemother.
34, 2223 (1990),
Abstract;
Full Text
Synthesis and biological properties of A-71497: a prodrug of tosufloxacin: D.T. Chu, et al.; Drugs Exp. Clin. Res.
16, 435 (1990),
Abstract;
